Three medicinal plants viz Azadirachta indica A. Juss, Catharanthus roseus (L) G. Don and Curcuma longa L. were tested for their antibacterial efficacy against Staphylococcus aureus and Klebsiella pneumoniae via extracts obtained from soxhlation using petroleum ether, benzene, acetone and ethanol as solvents. The in-vitro antibacterial activity was performed by disc diffusion method. Among these extracts, ethanol has been found to be effective one. The ethanolic extract of all the plants were more active against both the bacterial pathogens. Maximum zone of inhibition 15 mm was recorded in Azadirachta indica. A. Juss against Staphylococcus aureus whereas it was 14 mm against Klebsiella pneumoniae showing that it is the most effective plant extract among the three plants used.