4-{4-(2-phenyl-4-benzylidene-5-oxo-imidazol-1-yl) phenyl}-6-(substituted phenyl)-1,2,5,6-tetrahydropyrimidin-2-thione have been prepared by the refluxation for 3 hours of 4-benzylidene-1-{4-[3-(substituted phenyl)prop-2-enoyl]phenyl}-2- phenyl -imidazol-5-one with thiourea and potassium hydroxide in presence of ethanol . The intermediate 4-benzylidene-1-{4-[3-(substituted phenyl)prop-2-enoyl]phenyl}-2- phenyl -imidazol-5-one synthesized by the condensation of 1-(4-acetylphenyl)-4-benzylidene-2- phenyl- imidazol-5-one with various aldehydes. The product is characterized by spectral and analytical data. Most of the tested compounds show promising antibacterial and antifungal activity.
Copy the following to cite this article:
R. Shah; P. S. Patel; D. Trivedi; P. Vyas, "Synthesis and characterization of 4-{4-(2-phenyl-4-benzylidene-5-oxo-imidazol-1-yl) phenyl}-6-(substituted phenyl)-1,2,5,6-tetrahydropyrimidin-2-thione derivatives and study of their antimicrobial activities", Journal of Ultra Chemistry, Volume 6, Issue 1, Page Number 15-18, 2018Copy the following to cite this URL:
R. Shah; P. S. Patel; D. Trivedi; P. Vyas, "Synthesis and characterization of 4-{4-(2-phenyl-4-benzylidene-5-oxo-imidazol-1-yl) phenyl}-6-(substituted phenyl)-1,2,5,6-tetrahydropyrimidin-2-thione derivatives and study of their antimicrobial activities", Journal of Ultra Chemistry, Volume 6, Issue 1, Page Number 15-18, 2018Available from: http://www.journalofchemistry.org/paper/626/