Synthesis of a new drug delivery system based on chitosan for controlled release of Ephedrine
Department of Chemistry, Science Faculty, Islamic Azad University Arak Branch Arak Iran
Email:-m-sadeghi@iau-arak.ac.in
The present work focused on the design of drug delivery system (DDS) based on a pH-sensitive hydrogel. The hydrogels were prepared via graft copolymerization of acrylonitrile (AN) and acrylic acid (AA) monomers were directly grafted onto chitosan using ammonium persulfate (APS) as an initiator and methylenebisacrylamide (MBA) as a crosslinking agent under an inert atmosphere. Sodium bicarbonate (NaHCO3) was added to function as a foaming agent under acidic conditions, rendering the hydrogels to be porous. Porous structure of hydrogel was essential in this system to yield a large surface area so that Ephedrine release could be facilitated. Due to the reversible swelling behavior of the hydrogels, the synthesized networks can sense the environmental pH change and achieve an oscillatory release pattern. The concentration of released Ephedrine loaded was monitored at 276 nm on the UV spectrophotometer.
Copy the following to cite this article:
Mohammad Sadeghi*, Fatemeh Soleimani and Hossein Sadeghi , "Synthesis of a new drug delivery system based on chitosan for controlled release of Ephedrine ", Journal of Ultra Chemistry, Volume 7, Issue 3, Page Number 403-412, 2016Copy the following to cite this URL:
Mohammad Sadeghi*, Fatemeh Soleimani and Hossein Sadeghi , "Synthesis of a new drug delivery system based on chitosan for controlled release of Ephedrine ", Journal of Ultra Chemistry, Volume 7, Issue 3, Page Number 403-412, 2016Available from: http://www.journalofchemistry.org/paper/520/
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