This paper deals the alteration in physico-chemical parameters of river Gomti due to continous daily addition of raw municipal sewage and effluents from Lucknow City. pH., B.O.D., C.O.D, heavy metals including toxic chemical like fluoride and chloride were periodically tested at different sampling stations from June 2004 to Dec. 2004. Most of the parameters have gone high whereas D.O. has decreased significantly. Samples were highly contaminated which has gradually increased from upward to down ward stream (i.e. west to east part of the river). The altered conditions are hazardous for the survival of aquatic life and human health.