Journal of Chemistry

Synthesis of 2-imino-4-oxo-thiazolidino based quinoxalinediones as antitubercular agents

Author & Affiliation:
P.Y. PAWAR
P.D.V.V.P. Fs, College of Pharmacy, Post MIDC, Vilad Ghat, Ahmednagar - 414 111, (MS) INDIA
S.B. BHISE
Government College of Pharmacy, Karad - 415 124 (MS) INDIA
Keyword:
Quinoxaline-2, antitubercular activity
Issue Date:
December 2008
Abstract:

6,7-bis[3-(4-substitutedphenyl)-4-oxo-thiazolidin-2-ylideneamino] quinoxa line-2,3(1H,4H)-diones (3a-e) have been synthesized by cyclisation of 6,7-bis[3'-aryl thiocarbamido]-quinoxaline-2,3(1H, 4H)-diones (2a-e) in presence of mono-chloroacetic acid, sodium acetate and glacial acetic acid. 6,7-Bis[3'-aryl thiocarbamido]-quinoxaline-2,3(1H,4H) -diones were obtained by reaction of 6,7-diaminoquinoxaline-2,3(1H,4H)-dione with substituted aromatic isothiocyanate. The constitution of the synthesized compounds is supported by IR, 1H NMR, Mass and elemental analysis. The compounds were subjected to preliminary in-vitro evaluation for antitubercular activity against Mycobacterium tuberculosis H37RV strain.
 

Pages:
189-194
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
DOI:
juc

Copy the following to cite this article:

P. Pawar; S. Bhise, "Synthesis of 2-imino-4-oxo-thiazolidino based quinoxalinediones as antitubercular agents ", Journal of Ultra Chemistry, Volume 4, Issue 2, Page Number 189-194, 2018

Copy the following to cite this URL:

P. Pawar; S. Bhise, "Synthesis of 2-imino-4-oxo-thiazolidino based quinoxalinediones as antitubercular agents ", Journal of Ultra Chemistry, Volume 4, Issue 2, Page Number 189-194, 2018

Available from: http://www.journalofchemistry.org/paper/729/

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