Journal of Chemistry

Synthesis and anticonvulsant activity of  2-(substituted phenylimino)-3-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl)-1, 3-thiazolidin-4-one

Author & Affiliation:
Siddiqui N.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jami Hamdard (Hamdard University), Hamdard Nagar, New Delhi - 110062 (INDIA)
Arshad M.F.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jami Hamdard (Hamdard University), Hamdard Nagar, New Delhi - 110062 (INDIA)
Khan S.A.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jami Hamdard (Hamdard University), Hamdard Nagar, New Delhi - 110062 (INDIA)
Keyword:
Thiadiazole, Thiazolidinones, Anticonvulsant, Neurotoxicity
Issue Date:
December 2008
Abstract:


Some 2-(substituted phenylimino)-3-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl)-1, 3-thiazolidin-4-ones were synthesized in good yields by appropriate synthetic route and characterized on the basis of spectral data and elemental analysis. The compounds were evaluated for anticonvulsant activity. The compounds 4a, 4c, 4e, 4f, 4i and 4j were potent in MES test and were less neurotoxic comparable to standard drug phenytoin.
 

Pages:
175-178
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
DOI:
juc

Copy the following to cite this article:

S. N.; A. M.f.; K. S.a., "Synthesis and anticonvulsant activity of  2-(substituted phenylimino)-3-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl)-1, 3-thiazolidin-4-one ", Journal of Ultra Chemistry, Volume 4, Issue 2, Page Number 175-178, 2018

Copy the following to cite this URL:

S. N.; A. M.f.; K. S.a., "Synthesis and anticonvulsant activity of  2-(substituted phenylimino)-3-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl)-1, 3-thiazolidin-4-one ", Journal of Ultra Chemistry, Volume 4, Issue 2, Page Number 175-178, 2018

Available from: http://www.journalofchemistry.org/paper/726/

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