Synthesis and comparative study for anti-inflammatory and antidiabetic activities of 3-dialkyl amino methyl vs 3-diphenylamino methyl 2, 4-thiazolidinediones
A number of 2, 4-thiazolidinedione derivative having dialkyl amine/diphenylamine appendage at N-3 position were synthesized and their anti-inflammatory and antidiabetic activities were evaluated. Some new derivatives were synthesized by reaction of 2, 4-thiazolidinedione and different aldehydes, which react with different dialkylamine. In order to confirm anti-inflammatory and anti-hyperglycemic activity, the reduction in the paw volume of carrageenan induced oedema in the albino rat compared to Diaclofenac sodium and the blood glucose levels were determined according to GOD-POD method in dexamethasone diabetic rats respectively. All the compounds were found active for their anti-inflammatory activity and glucose lowering capability.
Key words : 2, 4-Thiazolidinedione, anti-inflammatory activity, antidiabetic activity, hypoglycemic agents, antihyperglycemics and Dialkyl Amine containing 2,4-Thiazolidinedione.
Copy the following to cite this article:
K. Namdeo; S. K. Jiwane; B. Sharma; S. Prajapati, "Synthesis and comparative study for anti-inflammatory and antidiabetic activities of 3-dialkyl amino methyl vs 3-diphenylamino methyl 2, 4-thiazolidinediones", Journal of Ultra Chemistry, Volume 5, Issue 2, Page Number 153-158, 2018Copy the following to cite this URL:
K. Namdeo; S. K. Jiwane; B. Sharma; S. Prajapati, "Synthesis and comparative study for anti-inflammatory and antidiabetic activities of 3-dialkyl amino methyl vs 3-diphenylamino methyl 2, 4-thiazolidinediones", Journal of Ultra Chemistry, Volume 5, Issue 2, Page Number 153-158, 2018Available from: http://www.journalofchemistry.org/paper/699/
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