Journal of Chemistry

Synthesis and characterization of 4-{4-(2-phenyl-4-benzylidene-5-oxo-imidazol-1-yl) phenyl}-6-(substituted phenyl)-1,2,5,6-tetrahydropyrimidin-2-thione derivatives and study of their antimicrobial activities

Author & Affiliation:
R.A. Shah (Rajivmansa#yahoo.co.in)
Department of Chemistry Sheth l.H. Science College, MANSA-382845 (INDIA)
P. S. Patel (pspatel_mansa@yahoo.co.in)
Department of Chemistry Sheth l.H. Science College, MANSA-382845 (INDIA)
D.K. Trivedi
Department of Chemistry Sheth l.H. Science College, MANSA-382845 (INDIA)
P.J. Vyas
Department of Chemistry, Sheth M.N. Science College, Patan -384265 (INDIA)
Keyword:
mercapto, substitutedChalcones, dihydropyrimidin
Issue Date:
April 2010
Abstract:

 4-{4-(2-phenyl-4-benzylidene-5-oxo-imidazol-1-yl) phenyl}-6-(substituted phenyl)-1,2,5,6-tetrahydropyrimidin-2-thione have been prepared by the refluxation for 3 hours of 4-benzylidene-1-{4-[3-(substituted phenyl)prop-2-enoyl]phenyl}-2- phenyl -imidazol-5-one with thiourea and potassium hydroxide in presence of ethanol . The intermediate 4-benzylidene-1-{4-[3-(substituted phenyl)prop-2-enoyl]phenyl}-2- phenyl -imidazol-5-one synthesized by the condensation of 1-(4-acetylphenyl)-4-benzylidene-2- phenyl- imidazol-5-one with various aldehydes. The product is characterized by spectral and analytical data. Most of the tested compounds show promising antibacterial and antifungal activity.

 

 

Pages:
15-18
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
DOI:
juc

Copy the following to cite this article:

R. Shah; P. S. Patel; D. Trivedi; P. Vyas, "Synthesis and characterization of 4-{4-(2-phenyl-4-benzylidene-5-oxo-imidazol-1-yl) phenyl}-6-(substituted phenyl)-1,2,5,6-tetrahydropyrimidin-2-thione derivatives and study of their antimicrobial activities", Journal of Ultra Chemistry, Volume 6, Issue 1, Page Number 15-18, 2018

Copy the following to cite this URL:

R. Shah; P. S. Patel; D. Trivedi; P. Vyas, "Synthesis and characterization of 4-{4-(2-phenyl-4-benzylidene-5-oxo-imidazol-1-yl) phenyl}-6-(substituted phenyl)-1,2,5,6-tetrahydropyrimidin-2-thione derivatives and study of their antimicrobial activities", Journal of Ultra Chemistry, Volume 6, Issue 1, Page Number 15-18, 2018

Available from: http://www.journalofchemistry.org/paper/626/

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