Ziprasidone is a typical antipsychotic agent. Two simple, sensitive and accurate spectrophotometric methods have been developed for the determination of Ziprasidone hydrochloride (ZPD) in pure state and in its pharmaceutical formulations. The developed Method A is based on the reaction of the drug with 3-methyl-2-benzothiazolinone hydrazone in the presence of ferric chloride to form a colored species with ë_max 640 nm and Linearity in the range of 8-56 ìg/mL. Method B involves ion association complex formation of the drug with Methyl Orange. The developed chromogen in Method B shows maximum absorption at ë_max 420 nm and Linearity in the range of 3-15 ìg/mL. The results obtained were statistically evaluated and were found to be accurate and reproducible.