A kinetic study of dipolar protic solvent on ethyl nicotinate was highlighted by carrying out the varying composition from 30% to 70% (v/v) at five different temperature ranging from 20oc to 40 0c. The specific rate constant values of the reaction found to decrease with gradual addition of ethyl alcohol in water- ethanol media. The value of iso composition activation energy (Ec) and iso-dielectric energy (ED ) values of the reaction were found increase with increase proportion of ethyl alcohol in water- ethanol media. The number of water molecule associated with the activated complex is found to be decrease (1.230 to1.178) in water -ethanol media. The thermodynamic activation parameter such as H*, S*, and G* values of the reaction have been calculated.