The rate of alkaline hydrolysis of ethyl nicotinate was measured over the temperature range of 20oC to 40 oC in water-ethanol mixture at different composition 30 to 70% (v/v). The influence of solvent variation on reaction rate was examined in term of changes in the Activation parameter .increase of H* and S* values with simultaneous increase in G* of the reaction in media, reveals that the reaction is Enthalpy controlled and Entropy domination.
The Values of Iso-kinetic which is equal to 360, clearly indicates that there is appreciable interaction between solvent and solute present in the reaction media, i.e. reaction is ion-dipole.