1Kakatiya Institute of Technology and Sciences, Hasanparthy, Warangal, Telangana 506015
2Mahatma Gandhi Institute of Technology, Chaitanya Bharati, Gandipet, Hyderabad-500075 Telangana, (India)
3CKM Arts and Science College, Warangal, 506006Telangana (India)
4Jawaharlala Nehru Techological University Hyderabad, Kukatpally, Hyderabad-500 085 Telangana (India)
E-mail: mtcharya@yahoo.com
Ethyl 4-(trifluoromethyl)-1H-imidazole-5-carboxylate (1) and 2- Chloro-3-nitro-6-methoxypyridine react each other to offer Ethyl 4- (trifluoromethyl)-1-(6-methoxy-3-nitropyridin-2-yl)-1H-imidazole-5- carboxylate (2). Compound 2 cyclised with Sodiumdithionate to form 2- Methoxy-7-(trifluoromethyl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6(5H)- one(3) which on chlorination offers 6-Chloro-2-methoxy-7-(trifluoromethyl) imidazo[1,5-a]pyrido[3,2-e]pyrazine(4). The structures of all synthesized compounds were confirmed by IR, NMR and mass spectral data.
Copy the following to cite this article:
RANADHEER KUMAR M.1, LAXMINARAYANA E.2 VASUDHA MALLAM3 and THIRUMALA CHARY M4*, "A facile synthesis of 6-Chloro-2-methoxy-7-(trifluoromethyl) imidazo[1,5-a]pyrido[3,2-e]pyrazine", Journal of Ultra Chemistry, Volume 12, Issue 2, Page Number , 2016Copy the following to cite this URL:
RANADHEER KUMAR M.1, LAXMINARAYANA E.2 VASUDHA MALLAM3 and THIRUMALA CHARY M4*, "A facile synthesis of 6-Chloro-2-methoxy-7-(trifluoromethyl) imidazo[1,5-a]pyrido[3,2-e]pyrazine", Journal of Ultra Chemistry, Volume 12, Issue 2, Page Number , 2016Available from: http://www.journalofchemistry.org/paper/418/