Journal of Chemistry

Synthesis and Evaluation of Some Novel Pyrazoles for Antinflammatory Studies

Author:
BRIJENDRA KUMAR SONI*1, G. DEVALA RAO2 and SHANTHARAM UMESH NAYAK3
Affiliation:

1MES College of Pharmacy, Bangalore india

2KVR Siddartha College of Pharmacy, Vijayawada India

Government College of Parmacy, Bangalore India

Email:- bksoni19@gmail.com

Keyword:
Issue Date:
December 2014
Abstract:

A series of novel pyrazoles were synthesized starting from 4- fluoro-3-chloroaniline by condensation with aromatic aldehydes to give chalcones which were cyclized with hydrazine to obtain pyrazoles. The chlorine replaced various aromatic amines to obtain the final derivatives. The final compounds evaluated for in vitro bovine serum denaturation assay and in vivo antinflammatory activity by carrageenan induced rat paw oedema. The study indicated the importance of chlorine at the para position of the aromatic ring in enhancing antiinflammatory activity. Correlation with enzyme inhibition scores also explained.

Pages:
145-154
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
DOI:
juc

Copy the following to cite this article:

BRIJENDRA KUMAR SONI*1, G. DEVALA RAO2 and SHANTHARAM UMESH NAYAK3, "Synthesis and Evaluation of Some Novel Pyrazoles for Antinflammatory Studies", Journal of Ultra Chemistry, Volume 10, Issue 3, Page Number 145-154, 2016

Copy the following to cite this URL:

BRIJENDRA KUMAR SONI*1, G. DEVALA RAO2 and SHANTHARAM UMESH NAYAK3, "Synthesis and Evaluation of Some Novel Pyrazoles for Antinflammatory Studies", Journal of Ultra Chemistry, Volume 10, Issue 3, Page Number 145-154, 2016

Available from: http://www.journalofchemistry.org/paper/313/

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