Podophyllotoxin finds a lot of scopes in pharmaceutical field as it show wide biological activities. Several analogues of podophyllotoxin were reported variety of biological activities such as cathartic, cytotoxic, antimitotic, anticancer, antitropical skin disease, antimalarial, virucidal, fungicidal etc. Experiment was carried out to synthesize 6, 6a-dihydro-2, 3-dimethoxy-9-methyl-11bH benzo [c] fluoren - 5, 7 dione and Synthesis of 6, 6a-dihydro-3-methoxy-2, 9-dimethyl-11 bH benzo [c] fluoren - 5, 7 dione. The products were re-crystallized in ethanol and characterized by spectrometric methods, IR, NMR and Mass spectroscopy. A yield of 82.72 and 83.6 percent were recorded respectively. The anti-mitotic activities of the synthesized analogues were examined by the onion root tip method with reference to b- apopicropodophyllin and Podophyllotoxin. In the present work, the synthetic analogues D and E have shown increased anti-mitotic activities with ID₅₀ of 2.005 x 10^-6 M and 2.260 x 10^-6M respectively with reference to standard and control

Nickel nanoparticles (NiNPs) have been the subject of extensive research over the past decade for a wide range of possible applications due to their exceptional strong catalytic activity, high compressive strength, free radical scavenging, and antibacterial property. In consequence of this, there has been a significant advancement in the methods of producing NiNPs, as well as in the suggested reaction processes and applications of these particles. The production, reaction mechanisms, and practical uses of NiNPs are reviewed in this work. NiNPs with sizes ranging from 1 to 100 nm can be manufactured in a number of different ways for use in both scientific and commercial contexts. Synthesis methods are divided into two categories: top-down methods and bottom-up methods which are subdivided into physical, chemical, and biological strategies. Extensive description has been given for the chemical processes involved in the creation of NiNPs, in particular those involved in biosynthesis approaches. The latest developments in the use of NiNPs in industries such as biomedicine, dye absorption, catalysis, supercapacitors, and dye-sensitized solar cells are reviewed. This work also provides
examples of the benefits and functions of NiNPs in catalyzing various processes.