A series of 6-substituted phenyl-2-(3’-substituted phenyl pyridazin-6'-yl)-2,3,4,5-tetrahydropyradazin-3-one has been synthesized. An appropriate aromatic hydrocarbon reacts with succinic anhydride in presence of AICI3 to yield (3-aroyl propionic acid. The corresponding acid was cyclised with hydrazine hydrate to give 6-(substituted aryl)- 2,3,4,5-tetrahydro-3-pyridazinone, which was heated on steam bath with phosphorous oxy chloride to yield 3-chloro 6-substituted phenyl pyradazine. This intermediate after reaction with hydrazine hydrate was converted into 3-hydrazino-6-substituted phenyl pyradazine. The resulting product was converted into 6-substituted phenyl-2-(3'- substituted phenyl pyridazin-6’-yl)-2,3,4,5-tetrahydropyradazin-3-one by reacting with substituted aroyl propionic acid. Spectral data (IR, NMR, mass spectra) confirmed the structures of the synthesized compounds. The synthesized compounds were investigated for their in vitro antituberculostic activity. The results indicated that the synthesized compounds have mild to potent activity with reference to their appropriate reference standards.
In this study, we investigated the physicochemical properties of cellulose obtained from rubber wood sawdust. Cellulose samples were isolated from rubber wood sawdust by a two stage treatment at 100°C with 8 or 10% HNO3 for l h followed by l% NaOH for 30min and also using 6.3% NaCICb, pH 3.6 at 75°C, followed by treatment with 17.5% NaOH for 2 hours. The structural properties of the cellulose samples were comparatively examined using Fourier transformed infrared spectroscopy (FTIR) and X-ray diffraction (XRD), and their thermal stability and morphology were determined using thermogravimatory analysis (TGA) and scanning electron microscopy (SEM) respectively. The results obtained showed that rubber wood sawdust posses good structural properties and thermal stability. Thus, it can be a potential raw material in fiber based applications such as making of paper and composites materials.
The present study was performed to investigate the pharmacodynamic and nephrotoxic effect of royal jelly. Royal jelly stimulate the contractility of guinea pigs ileum, rat's colon and rabbits duodenum, this stimulant effect might be due to increasing influx of calcium ion. Royal jelly had direct myogenic action on uterine muscle at different stages of sex cycle, and also had positive inotropic effect on guinea pig's auricle and rabbit heart. 15 mg /kg. body wt of royal jelly was prodcued hypotensive effect in anasthetized dog due to direct relaxant effect of royal jelly on vascular muscle, on the other hand royal jelly had significant antipyretic and analgesic effect in rats. About nephrotoxic effect, royal jelly produced highly significant increase in serum creatinin and urea with significant decrease in creatinine and urea clearance. Royal jelly had significant hypoglycemic effect which migh be attributed to, the royal jelly had insulin like effect which reduced blood glucose level.
Polarographic technique has been used to determine binary complex formation between Cd(II) and atenolol at25°C. DeFord and Hume graphical method as improved by Irving is used to calculate the overall stability constants of the complexes. Atenolol forms [Cd(Atnl)]2+ and [Cd(Atnl)2]2+ complexes at p=1.0 M (NaNCh). The values of overall formation constants are log Pi = 1.60, log P2 = 3.77 at pH = 8.5.
Some mixed - ligand hydridophosphine complexes of Pd°, Pt° and Rh’ have been prepared and oxidative addition as well as coordinative displacement reactions are examined. The secondary ligand used in the study is I, 2, 4 - triazole -3(s) thione. All solid isolated products are characterized using elemental analyses, Magnetic measurement, conductivity, IR, UV - Vis and IH NMR spectral data.
Ultrasonic velocities and ultrasonic densities of 3 (2'- aminophenyl)- 4-pyridoyl - 5 (2- hydroxyl phenyl) pyrazoles, in 70% acetone-water have been evaluated at 308.15 K by using interferometer at a frequency of 2.0 MHz. The ultrasonic velocity, density and concentration were used to calculate, partial molal volume (^v) apparent molar compressibility, intermolecular free length (Lf), Adiabatic compressibility (fis) Specific acoustic impedance (Z) and Relative association (RA) to throw the light on the solute-solute interaction and solute-solvent interaction.
Stability of Y(III), La(III), Ce(IIl), Pr(III),Nd(III), Sm(III), Gd(III), Dy(Ill) and Th(IV) complexes of Creatine was studied at 30°C in 10%, 20%, 30%, 40%, 50%, 60% v/v dioxane-water mixtures and ionic strength was maintained as 0.2M (NaClO-i). Titration data was obtained on the basis of Irving-Rossotti technique and data was pruned with computer program PKAS & BEST. Species distribution plots are developed using program SPEPLOT. The active forms of species observed were LH2, LH+, L, ML, ML? and ML(OH)3. The effects of systematic errors on stability constants are studied using concept of modeling. The order for these effects is: dissolved carbon dioxide > alkali > acid > ligand > metal. The stability of inner transition metal -creatine complexes has increased with increasing dioxane content in mixtures. The change in stability constants with change in dielectric constant of medium is explained on the basis of cation solvating nature of cosolvent, specific solvent-water interaction, specific interaction of cosolvent with solute, electrostatic and non-electrostatic effects.
Mixed ligand systems (trimethylolpropanetrithioglycolate -alaninate, trimethylolpro-panetrithioglycolate - aspartate, trimethylolpro-panetrithioglycolate glutaminate, trimethylolpropa- netrithioglycolate valinate, with Cd(II), Pb(ll) and Tl (I) in aqueous-non aqueous (3:1 v/v aqueous ethanol) media at constant ionic strength (KNOj, p = 1.0 M), pH (6.2 ± 0.02) and temperature (303 ± 2K) have been studied polarographica'lly.
Triton X-100 (0.001 %) was used as wave maxima suppressor. It was shown that only one mixed ligand entity (MaixO is formed in case of trimethylolpropanetrithioglycolate alaninate/ aspartate/ glutaminate/ valinate systems (where 'i' is three forCd(ll) and Pb(II), and one for TI(I), j is one for all complexes formed) A and X are trimethylolpropane-trithioglycoiate and alaninate/ aspartate/ glutaminate/ valinate/ respectively. Compositions and stability constants of the single mixed ligand species formed have been evaluated employing Souchay and Faucherr's method.
Voltammetry has been used to determine the mixed ligand complex formation between Cd(II) with alanine (an amino acid) as primary ligand and atenolol (P-Blocker) as a secondry ligand. Cd formed only one ternary complex 1:1:1. The extended method of Schaap and McMasters has been used to evaluate the stability constant of this complex.
Organometallic complexes of ruthenium (II) having general formula [RuH(CO(P<|>3Xligand)2CI] with isomeric 1 -chloro phenyl and 1 -methoxy phenyl derivatives of substituted tetrazoline-5-thione have been synthesized and characterized on the basis of elemental analysis, conductance measurement, lr, IHNMR and electric spectral studies. Bonding of ligand occurs through thione tantomeric form and trans-octahedral structure of complexes have been assigned.