In the present paper we report the preparation and characterisation of a few homobinuclear metal complexes of the type [ML^1-2(H₂O)₂] ₂X₂ with a pair of NNSO Schiff base, L¹ = 1-hydroxy-imino-1,2 diphenyl-3,4-diazo-5-amino-5-mercapto-2-pentene (HAPAME) and L² = 2-hydroxy-imino-3-methyl-4,5-diazo-6-mercapto-6-amino-3-hexane (HAMAME). M = Co(II), Ni(II) and Cu(II) and X = Cl^-, Br^-, NO₃^-, ClO₄^- and CH₃COO^-. Structural elucidation has been done on the basis of infrared spectra, electronic spectra, magnetic susceptibility, conductivity measurement and thermal analysis. On the basis of above observations, the ligands HAPAME/HAMAME coordinate to the metal ion in a tetradentate fashion and structure of the complexes proposed to be octahedral in nature.
 

4-fluoro-3-chloro-anilin(1) react with various aromatic aldehydes(2) under mild acid catalysed conditions to get 4-fluoro-3-chloro-arylednes (3). These aryledenes were further reacted with hydrazine hydrate to get 4-fluoro-3-hydrazino-arylidenes (4), which further reacted with acetylacetone to afford compounds. 3,5-dimethyl (-N-2¹-fluoro-5¹-(3,4,5-trimethoxyaryledene) pyrazole (6b) has shown marked activity against E. Coli and S. aureus. at 100mcg and 200mcg concentration.

[6-oxo-3-(substituted phenyl)-5,6-dihydro-4H-pyridazine-1-yl] acetic acid hydrazide derivatives were synthesized from [6-oxo-3-(p-substituted phenyl)-5,6-dihydro-4H-pyridazine-1-yl] acetic acid ethyl ester. Friedal craft acylation of substituted aromatic hydrocarbon in the presence of anhydrous aluminium chloride yield b-( p-substituted benzoyl) propionic acid. After the reaction with hydrazine hydrate the b-(p-substituted phenyl) propionic acid yield 6-(p-substituted phenyl)-2,3,4,5-tetrahydro-pyridazine-3-one that on reaction with ethylbromoacetate yield ethyl ester of the appropriate pyridazinone. The final compounds were synthesized by reaction of [6-oxo-3-(p-substituted phenyl)-5,6-dihydro-4H-pyridazine-1-yl] acetic acid ethyl ester with hydrazine hydrate. The synthesized compounds were tested for anticonvulsant activity by MES (maximal electro shock) method.
 

A series of complexes of general formula [M(L^1-2)₂X₂] where M = Co(II), Ni(II) and Cu(II); and X = Cl^-, Br^- and I^- and L¹ = Isobenzofuran 1 (3H) one semicarbazone; L² = Isobenzofuran 1 (3H) one thiosemicarbazone have been synthesized. The geometry of the complexes have been characterized by elemental analysis, molar conductance, thermal analysis, spectral study (IR and UV) and magnetic susceptibility measurements. Octahedral geometry is tentatively proposed for all the complexes. Antimicrobial activity of the ligand and metal complexes were screened and observed that metal complexes were found to be more active than free ligands.
Key word: Isobenzofuran semicarbazone/thiosemicarbazone, metal complexes, antimicrobial activity.

Chemical liquid waste of drug industries contain total coliform (TC) and drug resistance bacteria (DRB). In present study chemical waste is analyzed to determine the total coliform (TC) and drug resistance Bacteria (DRB). Sample were collected from industries outlets, which adjoin in municipal nails and near by and treatment plants situated at mandideep. During sampling, preservation and analysis of samples standard method prescribed by APHA were followed maximum counts of TC (29 X10⁵) reported at after confluence of industrial waste in waste reservoir. while minimum number of TC (15X10⁵) was reported before confluence of drain with water reservoir. DRB increased when chemical effluent mixed with water reservoir.

Ovpa complexes with lanthanides behaves as a bidentate ligand coordinating through phenolic oxygen and azomethine nitrogen. The valency of the metal ion is neutralized by these ligand molecules and anions (chloride, acetate) thus leading to the formation of a stable neutralized structure. The other coordination sites are occupied by water molecule.

Samples of lamprophyric pillow lavas and plugs from Central Iran have been analyzed by NAA. The concentration of 28 elements, major and trace, are reported. Similar geochemical characteristics and parallel chondrite REE patterns of all samples, are remarkably thereby implying that they were all derived from a similar mantle source region and underwent similar melt extraction. These rocks are continental alkaline lamprophyres, that produced by low degree partial melting of upper mantle garnet lherzolites.

The ground water day by day get deteriorate or polluted due to contamination of chemicals as well as fertilizer, which comes form Factories, and big farms as well as domestic effluents. The major ions which are responsible to maintain the quality of ground water are carbonate and bicarbonate, Chloride, sulphate, nitrate, phosphate, fluoride. These ions are present in anionic form. The cation and anion must be equal to maintain the quality of water cation such as Ca²⁺, Mg²⁺,Na⁺ and K⁺ are also present in ground water in form of hardness and salinity. 10 water samples are collected from Mehgao block (Bhind District) for pre-mansoon season (April to June 2005) The ionic concentration is expressed in mg/L.
 

Ancient scriptures on Ayurveda recommended medicinal use of O. americanum. Current investigator evaluates paradoxical nature of O. americanum. The toxic effects of plant extract were studied on the life cycle, growth and mortality of beetle Tribolium confusum in stored rice grain. The survival rate of beetle is significantly reduced in the grains treated with leaves of plant extract. Metals in plant extract were found to be as zinc (88 µg/g), iron (120 µg/g), copper (56 µg/g) and manganese (21 µg/g). These trace metals impart therapeutic values to this herb specified in Indian Ayrvedic Medicinal System.