Journal of Chemistry

Papers

Voulume: 3
Issue: 2
Article No. 1
Kinetics of the oxidation of oxyhaemoglobin by Sodium Nitrite
DILIP B. PATIL
Department of Chemistry, Institute of Science,Nagpur - 440001 (INDIA)
PRAKASH R. KAKDE
Department of Chemistry, Institute of Science,Nagpur - 440001 (INDIA)
Abstract :

The kinetics of the oxidation of oxyhaemoglobin by sodium nitrite has been studied spectrophotometrically. The reaction has been shown to be second order with specific reaction rate of 4.2 x 101 M-1s-1 at 25.0oC and  at pH 6.80(Phosphate buffer). The energy of activation, frequency factor and entropy of activation are found to be 57.94 kJM-1, 5.994 x 1011 s-1 and -27.68 JK-1mol-1 respectively. In order to probe inside the mechanism, the effect of ionic strength is also investigated. The most likely mechanism is suggested for the reaction.    

 

Keyword : oxyhaemoglobin, methaemoglobin, oxidation, sodium nitrite
DOI : juc
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Article No. 2
Thermogravimetric Analysis of Tercopolymer Resins Derived from 8-Hydroxyquinoline, Dithiooxamide and Formaldehyde
S.S. Katkamwar
Department of Chemistry, Laxminarayan Institute of Technology, Nagpur - 440010 (INDIA)
A.B. Zade
Department of Chemistry, Laxminarayan Institute of Technology, Nagpur - 440010 (INDIA)
W.B. Gurnule (wbgurnule@yahoo.co.in)
Department of Chemistry, Kamla Nehru College, Nagpur - 440009 (INDIA)
Abstract :

Tercopolymers were prepared by the condensation of 8­hydroxyquinoline (8-HQ), dithiooxamide (D) and formaldehyde (F) in the presence of hydrochloric acid (2M) as catalyst with varying molar ratio of reacting monomers. Tercopolymers were characterized by their electronic absorption spectra, NMR spectra, IR spectra, elemental analysis and TGA. Molecular weight of tercopolymer were determined by non-aqueous conductometric titration. The kinetic and thermodynamic parameters such as order of reaction, energy of activation, frequency factor, entropy charge, free energy change and apparent entropy change have been determined. Freeman Carroll and sharp Wentworth method have been applied for the calculation of kinetic parameters while the data from the Freeman-Carroll method have been used up to determine various thermodynamic parameters. The static (isothermal) TG data were analysed by use of Sharp-Wentworth method and Freeman-Carroll method. The activation energy of the tercopolymers were calculated and it was observed that the 8-HQDF-IV was more stable than those of 8-HQDF-I, 8­HQDF-II and 8-HQDF-III. This prediction on the basis of static TG data is an agreement with the prediction based on the activation energies and initial decomposition temperatures calculated from the dynamic TG curves.

Keyword : activation energies, decomposition temperatures
DOI : juc
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Article No. 3
Kinetics of oxidation of phenylalanine and phenylglycine by bromine
DILIP B. PATIL
Department of Chemistry, Institute of Science, Nagpur - 440001 (INDIA)
SUNIL D. CHACHERE
Department of Chemistry, Institute of Science, Nagpur - 440001 (INDIA)
Abstract :

 

The kinetics of oxidation of phenylalanine and phenylglycine by bromine have been investigated electrochemically. Both the reactions shown to be overall of second order. The specific reaction rate for phenylalanine is 0.18 x 102 M-1 s-1 and 0.50 x 102 M-1 s-1 for the phenylglycine at 25.0oC. The energy of activations, frequency factors and entropy of activations in case of phenylalanine and phenylglycine are found out to be 65.10 kJ mol-1, 4.64 x 1012 s-1, -10.70 J K-1 mol-1 and 63.19 kJ mol-1, 5.96 x 1012 s-1, -8.63 J K-1 mol-1 respectively. From results likely mechanism has been proposed.    

 

Keyword : phenylalanine, phenylglycine, oxidation, bromine
DOI : juc
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Article No. 4
Synthesis and characterization of new inorganic ion exchanger-antimony (III) silico mpl ybdo tungstate and it's application in pharmacuetical field
SINDHOORA RAGHAVAN
Department of Chemistry, Sree Narayan Post Graduate College and Research Centre, Kanpur- 670 007, Kerala (INDIA)
C. JANARDANAN
Department of Chemistry, Sree Narayan Post Graduate College and Research Centre, Kanpur- 670 007, Kerala (INDIA)
Abstract :

A new inorganic ion exchanger, Antimony (III) Silico Molybdo Tungstate [Sb(III)Si MoW] has been prepared and characterized. The ion exchange capacities, distribution coefficients of 12 metal ions, effect of temperature and electrolyte concentrations on ion exchange capacity have been studied. The exchanger has been characterized by TG, XRD and IR studies. On the basis of difference in distribution coefficients (Kd), binary separations carried out are the separation of Al (III) from Hg (II), Cu (II), Cd (II), Ni (II) and Th (IV). The importance of the exchanger is revealed by checking the formulations of different antacid samples.          

 

Keyword : Ion exchanger,, Sb (III) SiMoW, Ion exchange capacity (i.e.c), Distribution coefficient (Kd)
DOI : juc
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Article No. 5
Properties of Sago Esters/Poly (vinylchloride) Blends
See Yaw Koon
Department of Chemistry, Faculty of Science, University Putra Malaysia - 43400 UPM, Serdang, Selangor (MALAYSIA)
Dzulkefly Kuang Abdullah
Department of Chemistry, Faculty of Science, University Putra Malaysia - 43400 UPM, Serdang, Selangor (MALAYSIA)
Atan Mohd. Sharif
Department of Chemistry, Faculty of Science, University Putra Malaysia - 43400 UPM, Serdang, Selangor (MALAYSIA)
Abstract :

Sago starch was chemically modified by esterification with fatty acid chlorides of different chain-lengths (hexanoyl, octanoyl and lauroyl chlorides) in the absence of an organic solvent.  The products with different degree of substitution (DS) were blended with poly(vinly chloride) (PVC) at various proportions by using conventional solvent-casting technique.  The blends were characterized by FT-IR and, their thermal, mechanical and water absorption properties were investigated as a function of blend composition.  Result of

FT-IR analysis showed that there was no intermolecular interaction between sago esters and PVC.  The existence of sago esters in the blends had enhanced the thermal properties of pure PVC plastic. The blends also exhibited satisfactory mechanical property up to 20 wt % of sago ester content where they still retain 80% of pure PVC mechanical properties and showed a minimal water uptake capacity (<4 wt%).           

 

Keyword : sago ester, esterification, poly(vinly chloride), blends, mechanical properties
DOI : juc
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Article No. 6
Nickel (II) ion sensing with Aradlite-matrix based membrane sensor - It's analytical application
J. Thamarai Selvi
Department of Chemistry, Avinashilingam University for Women, Coimbatore - 641 043, Tamilnadu, INDIA
S.V. Seeja
Department of Chemistry, Avinashilingam University for Women, Coimbatore - 641 043, Tamilnadu, INDIA
Abstract :

A heterogeneous precipitate have been as ion carriers of the preparation of Nickel (II) selective membrane sensors.  The electrodes give near-nernstian responses in the linear concentration range of 1N to 1x10-5 N with detection limits of the order of 10-5N.  The stable potentiometric signals are obtained with in a short time period of 7 seconds.  The effects of pH and the effect of medium have been studied found to give better responses. Selectivity coefficient values   evaluated using fixed interference method.  The sensors have also been as a indicator electrodes in potentiometric titrations of Nickel (II) ions with EDTA and its determination in alloy analysis.   

Key words : Nickel(II), Aradlite-matrix, .        

Keyword : Department of Chemistry, Avinashilingam University for Women, Coimbatore - 641 043, Tamilnadu, INDIA, Aradlite-matrix, selective membrane sensors
DOI : juc
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Article No. 7
"Thermodynamic studies of some ∞-naphthyl amine derivatives in DMF and THF solution at 313.15 K"
Shipra Baluja (shipra_baluja@rediffmail.com)
Department of Chemistry, Saurashtra University, Rajkot- 360 005 (Gujrat) - INDIA
Nilesh Godvani
Department of Chemistry, Saurashtra University, Rajkot- 360 005 (Gujrat) - INDIA
Nirmal Pandya
Department of Chemistry, Saurashtra University, Rajkot- 360 005 (Gujrat) - INDIA
Abstract :

Some new derivatives of a-naphthyl amine have been synthesized and characterized by TLC, IR, NMR and Mass spectra. Densities and ultrasonic velocities of these compounds have been measured over the wide composition range at 313.15 K in Dimethylformamide (DMF) and Tetrahydrofuran (THF). From these experimental data, various acoustical and thermodynamic parameters were evaluated. Some of these parameters are isentropic  compressibility (s), intermolecular free length (Lf), solvation number (Sn), relaxation strength (r), internal pressure (), free volume (Vf), Rao's molar constant (Rm), Vander Waals constant (b), molar compressibility (W) etc. The types of interactions in solutions of these compounds in DMF and THF are explained from the evaluated parameters.           

 

 

Keyword : Schiff bases, Ultrasonic Study, Acoustical Parameters, DMF, THF
DOI : juc
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Article No. 8
Novel modification in the structure of well-known Drug Ciprofloxacin
Pradeep Yadav (pradeepyadav78@gmail.com
Department of Chemistry, University of Rajasthan, Jaipur - 302004 (Rajasthan) INDIA
Usha Baloda
Department of Chemistry, University of Rajasthan, Jaipur - 302004 (Rajasthan) INDIA
Y.C. Joshi
Department of Chemistry, University of Rajasthan, Jaipur - 302004 (Rajasthan) INDIA
Abstract :

Reaction of [1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7- (1-piperazinyl)-quinolone-3-carboxylic acid with diazoazonium salt of 2-aminopyridine in acetonitrile to get 1-cyclopropyle-6-fluoro-4-oxo-7-[4-(pyridine-2-yldiazenyl)-piperazin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid derivative. This ciprofloxacin derivative again subjected to react with various -diketone in presence of sodium methoxide to get novel -diketone derivative of 1-cyclopropyle-6-fluoro-4-oxo-7-[4-(pyridine-2-yldiazenyl)-piperazin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid. Structures of these compounds were established on the basis of spectral studies viz. IR, 1H NMR etc.    

 

Keyword : spectral studies viz, derivative again
DOI : juc
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Article No. 9
Synthesis and antiinflammatory activity of 2,4,N-aryl-as-triazines
RAJESH ANTONY
Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, B.S.K. III Stage, Bangalore - 560085 (INDIA
SHANTHARAM.U
Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, B.S.K. III Stage, Bangalore - 560085 (INDIA
SHACHINDRA. L.N
Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, B.S.K. III Stage, Bangalore - 560085 (INDIA
L.V.G. NARGUND
Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, B.S.K. III Stage, Bangalore - 560085 (INDIA
Abstract :

The arylhydrizocyanacetamides (1) was prepared from the reaction of diazonium salts of substituted aniline with active methylene compounds such as cyanoacetamide.  The compounds were reacted with substituted phenyl  isothiocyanates in dry pyridine to give corresponding 2,4-N-aryl-as-1,2,4-triazine 3-thiones.  Some of the compounds show promising anti-inflammatory activity.

 

Keyword : thiones, phenylu00a0 isothiocyanates
DOI : juc
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Article No. 10
SYNTHESIS AND EVALUATION OF FLUORO-ULPHANILAMIDES AS POSSIBLE ANTI-MICROBIAL AGENTS
NIRMAL T. HAVANNAVAR
Department of Pharmaceutical, M.M. U. College of Pharmacy, Ramanagaram- 571511 (INDIA)
SHANTHARAM. U
Nargund College of Pharmacy, Dattatreya Nagar, BSK -III Stage, bangalore - 560085 (INDIA)
L.V.G. NARGUND
Abstract :

3-chloro-4-fluoroaniline  was  taken  in  dioxane,  solution  of p-toluenesulfonyl chloride in dioxane was added dropwise with stirring. Then the mixture was refluxed to get 3-chloro-4-fluorosulphanilamide. Solution of sulphanilamide in DMSO was refluxed with various primary and secondary amines to get 3-amino substituted fluorosulphanilamides.

 

Keyword : Fluoro-sulphanilamide, antibacterial activity
DOI : juc
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