Journal of Chemistry

Comparative study of Hypoglycemic activity of gliclazide to its silver complex

Author & Affiliation:
RASHIDA QURESHI
Department of Chemistry, Saifia College of Science & Education Bhopal (India)
MANISH SINGH
Department of Chemistry, Saifia College of Science & Education Bhopal (India)
Keyword:
Silver complex, ,Hypoglycemic Activity, Diabetes Melitus, Antidiabetics
Issue Date:
May 2019
Abstract:

Gliclazide, N-(4-Methyl Benzene Sulphonyl)-N-(3-azo bicycle (3,3,0-Oct-3-yl) urea trade name Diamicron, an oral hypoglycemic agent was used to synthesize its complex with Ag(I). The hypoglycemic activity of gliclazide was observed on experimental animals (dogs) and then compared with Ag Complex, using Folin-Wu method. Results reveals that the gliclazide Ag-Complex is more effective than that of parent drug.This blood sugar lowering effect of sulfonylureas seems to be related to the stimulation of insulin secretion. On the other hand many studies have strongly indicated the presence of long term or extra pancreatic action of sulfonylureas. The interesting observation on metal complex of oral sulfonylurea used as anti-diabetic agent for lowering blood sugar concentration may likely substantiates the use of these complex after extensive clinical studies.

Pages:
39-42
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
DOI:
http://dx.doi.org/10.22147/juc/150303

Copy the following to cite this article:

R. Qureshi; M. Singh, "Comparative study of Hypoglycemic activity of gliclazide to its silver complex", Journal of Ultra Chemistry, Volume 15, Issue 3, Page Number 39-42, 2019

Copy the following to cite this URL:

R. Qureshi; M. Singh, "Comparative study of Hypoglycemic activity of gliclazide to its silver complex", Journal of Ultra Chemistry, Volume 15, Issue 3, Page Number 39-42, 2019

Available from: http://www.journalofchemistry.org/paper/899/comparative-study-of-hypoglycemic-activity-of-gliclazide-to-its-silver-complex

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