Journal of Chemistry

Drug Delivery and Binding Analysis of Isoflavones with Special Reference to Chicken Egg Lysozyme

Author & Affiliation:
SANJUKTA BADHEI
School of Biological and Chemical Sciences, MATS University, Raipur, Chhattisgarh-492002 (India)
AMIT KUMAR DUTTA
School of Biological and Chemical Sciences, MATS University, Raipur, Chhattisgarh-492002 (India)
PIYUSH KUMAR THAKUR
School of Biological and Chemical Sciences, MATS University, Raipur, Chhattisgarh-492002 (India)
Keyword:
Lysozyme, Molecular docking, Drug delivery
Issue Date:
November 2018
Abstract:

Drug delivery is the formulations, technologies and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Dietary polyphenols are very essential and are widely studied due to their various biological activities like anti-cancerous, antibacterial, anti inflammatory, anti diabetic etc. Lysozyme is an enzyme having antibacterial property which is found in various types of birds, mammals and insects. Lysozyme has the capacity to cure various diseases by binding with various drugs and realizing them in their target site. So their binding at molecular level is essential in the field of pharmaceutics. The binding of isoflavones with chicken egg lysozyme have been investigated using viscometer, UV-Visible spectrophotometer, circular dichroism, spectroflurometer and molecular docking technique. Drug delivery has been studied by using experimental animal, testing of anti cancerous activity and histopathological study. CD results indicate that the polyphenols are capable to increase the helical content of lysozyme during binding process. Molecular docking studies have been performed to substantiate the experimental facts. It is observed that both the ligands bind near to Trp 62, Trp 63 and Trp 108. Binding free energies are obtained from docking results and PEARLS will in good correlation with each other for the protein– ligand complexes. The binding of dietary polyphenols with lysozyme at the molecular level suggests a further insight into the success of the drugs in pharmaceutics.

Pages:
156-162
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
DOI:
http://dx.doi.org/10.22147/juc/140602

Copy the following to cite this article:

S. Badhei; A. K. Dutta; P. K. Thakur, "Drug Delivery and Binding Analysis of Isoflavones with Special Reference to Chicken Egg Lysozyme", Journal of Ultra Chemistry, Volume 14, Issue 6, Page Number 156-162, 2018

Copy the following to cite this URL:

S. Badhei; A. K. Dutta; P. K. Thakur, "Drug Delivery and Binding Analysis of Isoflavones with Special Reference to Chicken Egg Lysozyme", Journal of Ultra Chemistry, Volume 14, Issue 6, Page Number 156-162, 2018

Available from: http://www.journalofchemistry.org/paper/893/drug-delivery-and-binding-analysis-of-isoflavones-with-special-reference-to-chicken-egg-lysozyme

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