Atenolol [RS),4-{2-hydroxy-3-isopropylaminopropoxy}phenylacetamide] is an antihypertensive drug, used primarily in cardiovascular diseases. The simple complexes of this drug with Pb(II) have been studied by direct current polarography at 25°C and 35°C. The reduction of all complexes is found to be reversible and diffusion controlled involving 2e_ in each case. Deford and Hume's treatment suggests that Atenolol forms 1 : 2 complexes (metal to ligand molar ratio) at 25°C and 35°C. Two very stable complexes PbR+ and PbR2 are identified at two temperatures at µ = 1 (1M KNO3). The values of overall formation constant (log b) obtained are 4.8448, 7.8644 at 25°C and 4.6976, 7.6732 at 35°C. The thermodynamic parameters (DG°, DH°, DS°) have also been reported.
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P. Dhingra; S. Sharma; R. Pandey, "POLAROGRAPHIC STUDY OF COMPLEXES OF Pb(II) WITH ATENOLOL AT D.M.E.", Journal of Ultra Chemistry, Volume 3, Issue 1, Page Number 55-60, 2018Copy the following to cite this URL:
P. Dhingra; S. Sharma; R. Pandey, "POLAROGRAPHIC STUDY OF COMPLEXES OF Pb(II) WITH ATENOLOL AT D.M.E.", Journal of Ultra Chemistry, Volume 3, Issue 1, Page Number 55-60, 2018Available from: http://www.journalofchemistry.org/paper/788/