We have synthesized (2E)-N-(3-chloro-4-fluorophenyl)-2-cyano-3-(methylthio)-3-[(substituted phenyl)amino]acrylamide by using different aryl amines and that reacted with hydrazine hydrate or 2,4-DNP to obtain series of 5-amino-N-(substituted-phenyl)-1-(substituted)-3-[(3-chloro-4-fluorophenyl) amino]-1H-pyrazole-4-carboxamide. The structures of new compounds were established on the basis of spectral and elemental analysis. The title compounds were screened for anti-bacterial (agar diffusion method) and anti-oxidant activity (ferric ion reduction method) and inhibition of denaturation of protein. Most of the compounds have shown promising activity.
Copy the following to cite this article:
B. H. K.; D. Puranik; M. G; R. Jose; S. U; L. Nargund, "Synthesis of fluoro pyrazoles of Pharmacological interest", Journal of Ultra Chemistry, Volume 5, Issue 2, Page Number 169-176, 2018Copy the following to cite this URL:
B. H. K.; D. Puranik; M. G; R. Jose; S. U; L. Nargund, "Synthesis of fluoro pyrazoles of Pharmacological interest", Journal of Ultra Chemistry, Volume 5, Issue 2, Page Number 169-176, 2018Available from: http://www.journalofchemistry.org/paper/702/