Journal of Chemistry

Synthesis of fluoro pyrazoles of Pharmacological interest

Author & Affiliation:
Barot Hitesh K.
P.G. Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 (INDIA)
D.S. Puranik
P.G. Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 (INDIA)
Mallika G
P.G. Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 (INDIA)
Robin Jose
P.G. Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 (INDIA)
Shantharam U
P.G. Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 (INDIA)
L.V.G. Nargund
P.G. Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 (INDIA)
Keyword:
Fluoro Pyrazole, inhibition of denaturation of protein, anti-bacterial activity, anti-oxidant activity
Issue Date:
August 2009
Abstract:

We have synthesized (2E)-N-(3-chloro-4-fluorophenyl)-2-cyano-3-(methylthio)-3-[(substituted phenyl)amino]acrylamide by using different aryl amines and that reacted with hydrazine hydrate or 2,4-DNP to obtain series of 5-amino-N-(substituted-phenyl)-1-(substituted)-3-[(3-chloro-4-fluorophenyl) amino]-1H-pyrazole-4-carboxamide. The structures of new compounds were established on the basis of spectral and elemental analysis. The title compounds were screened for anti-bacterial (agar diffusion method) and anti-oxidant activity (ferric ion reduction method) and inhibition of denaturation of protein. Most of the compounds have shown promising activity.

 

 

Pages:
169-176
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
DOI:
juc

Copy the following to cite this article:

B. H. K.; D. Puranik; M. G; R. Jose; S. U; L. Nargund, "Synthesis of fluoro pyrazoles of Pharmacological interest", Journal of Ultra Chemistry, Volume 5, Issue 2, Page Number 169-176, 2018

Copy the following to cite this URL:

B. H. K.; D. Puranik; M. G; R. Jose; S. U; L. Nargund, "Synthesis of fluoro pyrazoles of Pharmacological interest", Journal of Ultra Chemistry, Volume 5, Issue 2, Page Number 169-176, 2018

Available from: http://www.journalofchemistry.org/paper/702/

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