Journal of Chemistry

DESIGN, SYNTHESIS AND DEVELOPMENT OF (11Z)-11-(4-SUBSTITUTED PHENYL) DIBENZO[b,f] [1,4] DIAZOCIN-6(5H)-ONES AS ANTICONVULSANTS

Author & Affiliation:
R. L. SAWANT
P.D.V.V.P.Fs College of Pharmacy, Vilad Ghat, Post - MIDC , Ahmednagar-414111 (MS) INDIA
M. S. BHATIA
Bharti Vidyapeeth College of Pharmacy, Kolhapur- 416 013 (MS) (INDIA)
JYOTI B. WADEKAR
Bharti Vidyapeeth College of Pharmacy, Kolhapur- 416 013 (MS) (INDIA)
Keyword:
Dibenzo, Topliss approach, Anticonvulsant activity
Issue Date:
December 2007
Abstract:

(11Z)-11-(4-Substitutedphenyl) dibenzo[b,f][1,4]diazocin-6(5H)-ones (2a-e) have been synthesized. The substituents at fourth position of the phenyl ring for initial and final set of compounds have been selected according to Topliss modified approach. The synthesized compounds were structurally characterized by TLC, elemental analysis, IR and NMR spectra studies. The anticonvulsant potential of synthesized compounds was evaluated by using Rotarod, Actophotometer and Electroconvulsometer. The anticonvulsant activity evaluation of initial set of compounds (2a-d) revealed that electron releasing substituents with high lipophilicity if placed at fourth position in phenyl ring should increase the anticonvulsant activity. Based on this observation, 4-dimethylamino substituted compound (2e) was synthesized and found to have increased activity.

 

Pages:
179-184
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
DOI:
juc

Copy the following to cite this article:

R. L. Sawant; M. S. Bhatia; J. B. Wadekar, "DESIGN, SYNTHESIS AND DEVELOPMENT OF (11Z)-11-(4-SUBSTITUTED PHENYL) DIBENZO[b,f] [1,4] DIAZOCIN-6(5H)-ONES AS ANTICONVULSANTS", Journal of Ultra Chemistry, Volume 3, Issue 2, Page Number 179-184, 2018

Copy the following to cite this URL:

R. L. Sawant; M. S. Bhatia; J. B. Wadekar, "DESIGN, SYNTHESIS AND DEVELOPMENT OF (11Z)-11-(4-SUBSTITUTED PHENYL) DIBENZO[b,f] [1,4] DIAZOCIN-6(5H)-ONES AS ANTICONVULSANTS", Journal of Ultra Chemistry, Volume 3, Issue 2, Page Number 179-184, 2018

Available from: http://www.journalofchemistry.org/paper/660/

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