(11Z)-11-(4-Substitutedphenyl) dibenzo[b,f][1,4]diazocin-6(5H)-ones (2a-e) have been synthesized. The substituents at fourth position of the phenyl ring for initial and final set of compounds have been selected according to Topliss modified approach. The synthesized compounds were structurally characterized by TLC, elemental analysis, IR and NMR spectra studies. The anticonvulsant potential of synthesized compounds was evaluated by using Rotarod, Actophotometer and Electroconvulsometer. The anticonvulsant activity evaluation of initial set of compounds (2a-d) revealed that electron releasing substituents with high lipophilicity if placed at fourth position in phenyl ring should increase the anticonvulsant activity. Based on this observation, 4-dimethylamino substituted compound (2e) was synthesized and found to have increased activity.
Copy the following to cite this article:
R. L. Sawant; M. S. Bhatia; J. B. Wadekar, "DESIGN, SYNTHESIS AND DEVELOPMENT OF (11Z)-11-(4-SUBSTITUTED PHENYL) DIBENZO[b,f] [1,4] DIAZOCIN-6(5H)-ONES AS ANTICONVULSANTS", Journal of Ultra Chemistry, Volume 3, Issue 2, Page Number 179-184, 2018Copy the following to cite this URL:
R. L. Sawant; M. S. Bhatia; J. B. Wadekar, "DESIGN, SYNTHESIS AND DEVELOPMENT OF (11Z)-11-(4-SUBSTITUTED PHENYL) DIBENZO[b,f] [1,4] DIAZOCIN-6(5H)-ONES AS ANTICONVULSANTS", Journal of Ultra Chemistry, Volume 3, Issue 2, Page Number 179-184, 2018Available from: http://www.journalofchemistry.org/paper/660/