Journal of Chemistry

SYNTHESIS AND ANTICONVuLSANT ACTIVTTY OF 6-(3'- NITROPHENYL)-4-SUBSTITUTED BENZYLIDiNE-2,3,5-TRIHYDRO PYRIDAZIN-3-ONE

Author & Affiliation:
Anees A Siddiqui
Jamia Hamdard, Hamdard Nagar, New Delh -62 (INDIA)
Mojahidul Islam
Jamia Hamdard, Hamdard Nagar, New Delh -62 (INDIA)
Mohd. Asif
Institute of Pharmacy, Bundelkhand University, Jhansi, UP. (INDIA)
Chavi Asthana
Institute of Pharmacy, Bundelkhand University, Jhansi, UP. (INDIA)
Keyword:
Pyridazinone, Anticonvulsant activity..
Issue Date:
December 2007
Abstract:

6-(3'-nitrophenyl)-4-substituted benzylidine-2,3,5-trihydro pyridazin-3-one derivatives are synthesized from 6-(3'-nitrophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with substiuted aldehydes. Friedal craft acylation of benzene in presence of anhydrous aluminium chloride yield ß-benzoyl propionic acid. After nitration with H2SO4 and HNO3 of the propionic acid yield ß -m-nitrobenzoyl propionic acid, which is cyclised with hydrazine hydrate to form 6-(3'-nitrophenyt)-2,3,4,5-tetrahydro pyridazin-3-one. Ali the

final synthesized compounds are evaluated for anticonvulsant activity by MES (maximal electro shock) method.        

 

Pages:
173-178
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
DOI:
juc

Copy the following to cite this article:

A. A. Siddiqui; M. Islam; M. Asif; C. Asthana, "SYNTHESIS AND ANTICONVuLSANT ACTIVTTY OF 6-(3'- NITROPHENYL)-4-SUBSTITUTED BENZYLIDiNE-2,3,5-TRIHYDRO PYRIDAZIN-3-ONE", Journal of Ultra Chemistry, Volume 3, Issue 2, Page Number 173-178, 2018

Copy the following to cite this URL:

A. A. Siddiqui; M. Islam; M. Asif; C. Asthana, "SYNTHESIS AND ANTICONVuLSANT ACTIVTTY OF 6-(3'- NITROPHENYL)-4-SUBSTITUTED BENZYLIDiNE-2,3,5-TRIHYDRO PYRIDAZIN-3-ONE", Journal of Ultra Chemistry, Volume 3, Issue 2, Page Number 173-178, 2018

Available from: http://www.journalofchemistry.org/paper/659/

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