Reaction of [1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7- (1-piperazinyl)-quinolone-3-carboxylic acid with diazoazonium salt of 2-aminopyridine in acetonitrile to get 1-cyclopropyle-6-fluoro-4-oxo-7-[4-(pyridine-2-yldiazenyl)-piperazin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid derivative. This ciprofloxacin derivative again subjected to react with various -diketone in presence of sodium methoxide to get novel -diketone derivative of 1-cyclopropyle-6-fluoro-4-oxo-7-[4-(pyridine-2-yldiazenyl)-piperazin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid. Structures of these compounds were established on the basis of spectral studies viz. IR, 1H NMR etc.
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P. Yadav; U. B. ; Y. Joshi, "Novel modification in the structure of well-known Drug Ciprofloxacin", Journal of Ultra Chemistry, Volume 3, Issue 2, Page Number 137-140, 2018Copy the following to cite this URL:
P. Yadav; U. B. ; Y. Joshi, "Novel modification in the structure of well-known Drug Ciprofloxacin", Journal of Ultra Chemistry, Volume 3, Issue 2, Page Number 137-140, 2018Available from: http://www.journalofchemistry.org/paper/651/