Thiazolo[3,2-a] pyrimidin-5-ones: Design, Synthesis and Antimicrobial Evaluation
1Department of Chemistry, Bhagwan Mahavidyalaya, Ashti. Dist. Beed-414203(MS), India
2Post Graduate and Research Center, Maulana Azad College, Aurangabad- 431001(MS), India
3 Dr. Rafiq Zakaria College for Women, Aurangabad- 431001(MS), India
4Dr.BabasahebAmbedkarMarathawadaUniversity, Subcampus, Osmanabad (MS), India
Email address of Corresponding Author:mazahar_64@rediffmail.com
Bacterial and fungal infections represent one of the most common health problem that cause functional disability and other complications. Upcoming needs for the clinical drugs candidates for the improvement signifies an exciting and challenging approach to improve the clinical effectiveness of current drugs in the development of new therapeutic approaches. In the existing report, we here report our results for extensive SAR study of novel thiazolo pyrimidin-5-ones derivatives, synthesis, antibacterial and antifungal activity. We are happy to display our most active compounds 5a, 5d, 5e, 5i owned incredible antimicrobial and antifungal potency. Altogether, compound 5i was found to be a lead candidate, displayed maximum potency in both antifungal and antibacterial segments. These findings recommend the prospective to explore this series as antimicrobial and anti-fungal agents
Copy the following to cite this article:
BABASAHEB ZINE1, SUNIL JADHAV2, PRASHANT DIXIT4 and MAZAHAR FAROOQUI*2,3, "Thiazolo[3,2-a] pyrimidin-5-ones: Design, Synthesis and Antimicrobial Evaluation", Journal of Ultra Chemistry, Volume 13, Issue 2, Page Number 30-34, 2017Copy the following to cite this URL:
BABASAHEB ZINE1, SUNIL JADHAV2, PRASHANT DIXIT4 and MAZAHAR FAROOQUI*2,3, "Thiazolo[3,2-a] pyrimidin-5-ones: Design, Synthesis and Antimicrobial Evaluation", Journal of Ultra Chemistry, Volume 13, Issue 2, Page Number 30-34, 2017Available from: http://www.journalofchemistry.org/paper/544/
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