CMC-based biodegradable hydrogel as a drug delivery systems
Department of Chemistry, Science Faculty, Islamic Azad University Arak Branch Arak Iran
Email:-m-sadeghi@iau-arak.ac.in
In this work, synthesis and swelling behavior of a superabsorbent hydrogel based on carboxymethylcellulose (CMC) and polyacrylonitrile (PAN) were investigated. The physical mixture of CMC and PAN was hydrolyzed by NaOH solution to yield hydrogel, CMC-poly(NaAA-co-AAm). During alkaline hydrolysis, the nitrile groups of PAN were completely converted to a mixture of hydrophilic carboxamide and carboxylate groups followed by in situ crosslinking of the grafted PAN chains. the structure of the product was established using FTIR and SEM spectroscopies. The CMC-poly(sodium acrylate-co-acrylamide) hydrogel exhibited a pH-responsive swelling-deswelling behavior at pH's 3 and 9. This on-off switching behavior provides the hydrogel with the potential to control delivery of bioactive agents.
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Mohammad Sadeghi, Fatemeh Soleimeni and Hossein Sadeghi , "CMC-based biodegradable hydrogel as a drug delivery systems ", Journal of Ultra Chemistry, Volume 7, Issue 3, Page Number 395-402, 2016Copy the following to cite this URL:
Mohammad Sadeghi, Fatemeh Soleimeni and Hossein Sadeghi , "CMC-based biodegradable hydrogel as a drug delivery systems ", Journal of Ultra Chemistry, Volume 7, Issue 3, Page Number 395-402, 2016Available from: http://www.journalofchemistry.org/paper/519/
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