Podophyllotoxin-1,2,3-triazole-thiazolidinedione hybrids: Design, synthesis and biological evaluation
Department of Chemistry, Govt. M.V.M Bhopal India
Email:-darmukhtarchem@gmail.com
A series of 4β-substituted-1,2,3-triazole-thiazolidinedione hybrids of podophyllotoxin were synthesized by employing click chemistry approach. The terminal alkynes were prepared in two steps, the first step employs Knoevenagel condensation and the second step involves propargylation. These terminal alkynes were then condensed with azidopodophyllotoxin under click chemistry reaction conditions to get a series of target compounds. All these compounds were screened for their anticancer activity against two human cancer cell lines using sulforhodamine B assay and showed significant activities against both cancer cell lines.
Copy the following to cite this article:
MUKHTAR A. DAR* and SARITA SHRIVASTAVA, "Podophyllotoxin-1,2,3-triazole-thiazolidinedione hybrids: Design, synthesis and biological evaluation", Journal of Ultra Chemistry, Volume 11, Issue 1, Page Number 15-18, 2016Copy the following to cite this URL:
MUKHTAR A. DAR* and SARITA SHRIVASTAVA, "Podophyllotoxin-1,2,3-triazole-thiazolidinedione hybrids: Design, synthesis and biological evaluation", Journal of Ultra Chemistry, Volume 11, Issue 1, Page Number 15-18, 2016Available from: http://www.journalofchemistry.org/paper/414/
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
