Synthesis and biological evaluation of 4,5-dihydro-4- (4,5-dihydro-1-aryl -3-methyl -1h-pyrazol-4-yl)-1-phenyl- 3-methyl-1h-pyrazolo[3,4-d]pyrimidine-6-thiol
Chemistry Department, Shri R.R.Lalan College, Bhuj-Kutch-370001 (INDIA)
E-mail:pkchaudhari6698@gmail.com
The synthesis of 4,5-dihydro-4-(4,5-dihydro-3-methyl-1- phenyl-1H-pyrazol-4-yl)-1-aryl-3-methyl-1H-pyrazolo[3,4-d]pyrimidine- 6-thiol (I a-h) have been undertaken by the condensation of 1-Aryl 3- methyl-1H-pyrazol-5(4H)-one with thiourea and 5-chloro-3-methyl-1- phenyl-1H-pyrazole-4-carbaldehyde. The constitution of the products (I a-h) have been characterized by using elemental analysis IR, 1 NMR and mass spectral data. The products (a-h) were assayed for their in vitro biological assay like antibacterial activity towards gram positive and Gram negative bacterial strain and antifungal activity towards Aspergillus nigor MICC-282 and Candida albicans MTCC-227 at a concentration of 40 μg/ml.
Copy the following to cite this article:
PARTHIV KANTILAL CHAUDHARI, "Synthesis and biological evaluation of 4,5-dihydro-4- (4,5-dihydro-1-aryl -3-methyl -1h-pyrazol-4-yl)-1-phenyl- 3-methyl-1h-pyrazolo[3,4-d]pyrimidine-6-thiol", Journal of Ultra Chemistry, Volume 8, Issue 1, Page Number , 2016Copy the following to cite this URL:
PARTHIV KANTILAL CHAUDHARI, "Synthesis and biological evaluation of 4,5-dihydro-4- (4,5-dihydro-1-aryl -3-methyl -1h-pyrazol-4-yl)-1-phenyl- 3-methyl-1h-pyrazolo[3,4-d]pyrimidine-6-thiol", Journal of Ultra Chemistry, Volume 8, Issue 1, Page Number , 2016Available from: http://www.journalofchemistry.org/paper/350/
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