Synthesis and Evaluation of Some Novel Pyrazoles for Antibacterial and Antioxidant Activity
1MES College of Pharmacy, Bangalore india
2KVR Siddartha College of Pharmacy, Vijayawada India
3Government College of Parmacy, Bangalore India
Email:- bksoni19@gmail.com
A series of novel pyrazoles were synthesized starting from 4- fluoro-3-chloroaniline by condensation with aromatic aldehydes to give chalcones which were cyclized with hydrazine to obtain pyrazoles. The chlorine was replaced with various aromatic amines to obtain the final derivatives. Evaluation of antibacterial activity against Staphylococcus aureus and Escherechia coli highlights the importance of methyl substitution and requirement of high lipophilicity. Ferric ion reduction studies indicate the requirement of requirement of electron releasing aromatic substitutions for enhanced antioxidant activity
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BRIJENDRA KUMAR SONI*1, G.DEVALA RAO2 and SHANTHARAM UMESH NAYAK3, "Synthesis and Evaluation of Some Novel Pyrazoles for Antibacterial and Antioxidant Activity", Journal of Ultra Chemistry, Volume 10, Issue 3, Page Number 163-173, 2016Copy the following to cite this URL:
BRIJENDRA KUMAR SONI*1, G.DEVALA RAO2 and SHANTHARAM UMESH NAYAK3, "Synthesis and Evaluation of Some Novel Pyrazoles for Antibacterial and Antioxidant Activity", Journal of Ultra Chemistry, Volume 10, Issue 3, Page Number 163-173, 2016Available from: http://www.journalofchemistry.org/paper/315/
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