The medicinal properties of plant species have made an outstanding contribution in the origin and evoluation of many traditional herbal therapies. A large number of people in both developing and developed countries rely on medicinal plant products to maintain their health or treat illness. Over the past few years however, the medicinal plants have regained a wide recognition due to an escalating faith in herbal medicine in view of its lesser side effects compared, to allopathic median medicinal plants, defined as plants used for maintaining health and treating illness are used in a plethora of ways in both allopathic and traditional systems of medicine in countries across the world.
Drug delivery is the formulations, technologies and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Dietary polyphenols are very essential and are widely studied due to their various biological activities like anti-cancerous, antibacterial, anti inflammatory, anti diabetic etc. Lysozyme is an enzyme having antibacterial property which is found in various types of birds, mammals and insects. Lysozyme has the capacity to cure various diseases by binding with various drugs and realizing them in their target site. So their binding at molecular level is essential in the field of pharmaceutics. The binding of isoflavones with chicken egg lysozyme have been investigated using viscometer, UV-Visible spectrophotometer, circular dichroism, spectroflurometer and molecular docking technique. Drug delivery has been studied by using experimental animal, testing of anti cancerous activity and histopathological study. CD results indicate that the polyphenols are capable to increase the helical content of lysozyme during binding process. Molecular docking studies have been performed to substantiate the experimental facts. It is observed that both the ligands bind near to Trp 62, Trp 63 and Trp 108. Binding free energies are obtained from docking results and PEARLS will in good correlation with each other for the protein– ligand complexes. The binding of dietary polyphenols with lysozyme at the molecular level suggests a further insight into the success of the drugs in pharmaceutics.
Asparagus racemosus (Shatawari) a climbing Ayurvedic plant and have numerous medicinal and therapeutic properties like phytoestroganic, antidepressant, antidiarrhoeal, anticancer etc. The objective of the present study was, phytochemical screening of ethanolic extract of roots of Asparagus racemosus. The phytochemical screening revealed the presence of flavonoids, steroids, tannins, glycosides terpenoids, Saponins. GC-MS analysis revealed the presence of various bioactive compounds confirms the application of Asparagus racemosus for various diseases.