Ziprasidone is a typical antipsychotic agent. Two simple, sensitive and accurate spectrophotometric methods have been developed for the determination of Ziprasidone hydrochloride (ZPD) in pure state and in its pharmaceutical dosage forms. The developed Method A is based on the formation of picrate salt between Picric acid and free base of ziprasidone and it shows maximum absorption at ë _max 400 nm and Linearity in the range of 4-20 ìg/mL. Method B involves reaction between free base of ziprasidone and Chloranilic acid. The developed chromogen in Method B shows maximum absorption at ë _max 520 nm and Linearity in the range of 16-36 ìg/mL. The results obtained were statistically evaluated and were found to be accurate and reproducible.