Journal of Chemistry

Papers

Voulume: 7
Issue: 3
Article No. 11
Studies of Some Metal Chelates of Niobium(V) with Thioamide Containing Ligand
R. N. Sharmaa1 and R. N. Pandey*

P.G. Centre of Chemisry (M.U.) College of Commerece, Patna India

Email:- rameshwarnath.pandey@yahoo.com

Abstract :

 Some complexes of 1-para substituted tetrazoline-5-thione withNb(V) have been synthesized and characterized on the basis of elemental analysis, conductometric measurement, I R, U V visible spectral studies. The p-tolyl, p-methoxy and p-chloro derivatives of 1-substituted tetrazoline-5-thione co-ordinate through thione sulphur and imino nitrogen with Nb(V) ions resulting deprotonation of imino nitrogen. All complexes show octahedral configuration. 

Keyword : Octahedral, spectral studies, Niobium, complexes
DOI : juc
Paper Download Count : 1
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Article No. 12
CMC-based biodegradable hydrogel as a drug delivery systems
Mohammad Sadeghi, Fatemeh Soleimeni and Hossein Sadeghi

Department of Chemistry, Science Faculty, Islamic Azad University Arak Branch Arak Iran

Email:-m-sadeghi@iau-arak.ac.in

Abstract :

 In this work, synthesis and swelling behavior of a superabsorbent hydrogel based on carboxymethylcellulose (CMC) and polyacrylonitrile (PAN) were investigated. The physical mixture of CMC and PAN was hydrolyzed by NaOH solution to yield hydrogel, CMC-poly(NaAA-co-AAm). During alkaline hydrolysis, the nitrile groups of PAN were completely converted to a mixture of hydrophilic carboxamide and carboxylate groups followed by in situ crosslinking of the grafted PAN chains. the structure of the product was established using FTIR and SEM spectroscopies. The CMC-poly(sodium acrylate-co-acrylamide) hydrogel exhibited a pH-responsive swelling-deswelling behavior at pH's 3 and 9. This on-off switching behavior provides the hydrogel with the potential to control delivery of bioactive agents. 
 

Keyword :  CMC; polyacrylonitrile; hydrogel; Ibuprofen; drug delivery.
DOI : juc
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Article No. 13
Synthesis of a new drug delivery system based on chitosan for controlled release of Ephedrine
Mohammad Sadeghi*, Fatemeh Soleimani and Hossein Sadeghi

Department of Chemistry, Science Faculty, Islamic Azad University Arak Branch Arak Iran

Email:-m-sadeghi@iau-arak.ac.in

Abstract :

The present work focused on the design of drug delivery system (DDS) based on a pH-sensitive hydrogel. The hydrogels were prepared via graft copolymerization of acrylonitrile (AN) and acrylic acid (AA) monomers were directly grafted onto chitosan using ammonium persulfate (APS) as an initiator and methylenebisacrylamide (MBA) as a crosslinking agent under an inert atmosphere. Sodium bicarbonate (NaHCO3) was added to function as a foaming agent under acidic conditions, rendering the hydrogels to be porous. Porous structure of hydrogel was essential in this system to yield a large surface area so that Ephedrine release could be facilitated. Due to the reversible swelling behavior of the hydrogels, the synthesized networks can sense the environmental pH change and achieve an oscillatory release pattern. The concentration of released Ephedrine loaded was monitored at 276 nm on the UV spectrophotometer. 

Keyword : chitosan, hydrogel, Ephedrine, releasing drug, sodium bicarbonate.
DOI : juc
Paper Download Count : 1
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Article No. 14
Simultaneously Graft Polymerization of Buthylmethacrylate and Acrylic acid Monomers onto Carboxymethylcellulose
Mohammad Sadeghi, Fatemeh Soleimeni and Hossein Sadeghi

Department of Chemistry, Science Faculty, Islamic Azad University Arak Branch Arak Iran

Email:-m-sadeghi@iau-arak.ac.in

Abstract :

Graft copolymerization of Buthylmethacrylate (BMC) and Acrylic acid (AcA) onto carboxymethylcellulose (CMC) was carried out under argon atmosphere in a homogeneous aqueous medium by using ceric ammonium nitrate (CAN) as an initiator. A plausible reaction mechanism of grafting has been suggested. Evidence of grafting was obtained by comparison of FTIR spectra of CMC and homopolymer-free CMC-g-poly(AcA-co-BMC) as well as solubility characteristics and gravimetric analysis of the products. The effect of the concentration of the initiator, monomers and polysaccharide as well as the reaction time and temperature on the graft copolymerization reactions were investigated to achieve the optimum grafting conditions. According to the empirical rates of the polymerization and the graft copolymerization of BMC and AcA onto CMC backbone, the overall activation energy of the graft copolymerization reaction was estimated to be 29.8 kJ/mol. 
 

Keyword : carboxymethylcellulose; Buthylmethacrylate; Acrylic acid;graft copolymerization.
DOI : juc
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Article No. 15
Impact of malathion on the serum of albino rats
B.K. Srivastava, Arvind Kumar and Grish Chandra*

Research lab, Department of Chemstry, Narain(P.G.) College, Shikohabad UP India

*Department of Chemistry, Janta College Bakewar UP India

Abstract :

Organophosphorus pesticides are mainly used in crop protection. Malathion in itself has only a slight direct inhibitory effect on mammals erythrocyte cholinesterase (ChE) and non specific esterases but one of its metabolite `malaoxon' is an active inhibitor. In this study experiments were carried out on male albino rats weighing 175 ± 25 gm. Malathion was orally administered for 6 days in increasing doses of 150, 300, 600 and 900 mg/kg to each rat. After completing the time rats were sacrificed and serum was obtained. The activity of Glutamyl Oxalo acetic Transaminase (GOT) and Glutmayl Pyruvate Transaminase (GPT) were studied for toxicological effect on the blood serum. Malathion treatment caused increase in serum GOT and GPT activity.

Keyword : serum
DOI : juc
Paper Download Count : 1
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Article No. 16
Investigations on Heavy Metal Uptake by Zingiber officinale from Metal Contaminated Soils during Cultivation
Jagrati Agrawal*1, Ruchi Sahu2, Nilima Bharadwaj3 and Kalpana S.4

Environmental Chemistry laboratory

1,2,4Department of Chemistry Govt College, Kota Tajasthan India

3Department of Botany, Govt. College, Kota Rajasthan India

Abstract :

Present investigations have been initiated to determine levels of uptake of heavy metals viz. Pb, Cd, Zn, Fe, Cu, and Mn to the usable part i.e. rhizome of Ginger plant. Samples of Ginger plant, a plant of wide spread utility and medicinal importance along with soil samples collected from fifteen different sites within and around industrial city Kota of Rajasthan, an industrial city, with high risk of heavy metal contamination. Samples were processed, digested and then metals were determined Atomic Absorption spectrophotometrically. Correlation matrix has shown that the most of the metal concentrations in plants and corresponding soil samples are significantly correlated. 
 

Keyword : Heavy metals, Medicinal plants, uptake, Atomic absorption spectrophotometer.
DOI : juc
Paper Download Count : 1
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Article No. 17
Investigation of Effective Parameters onto Graft Copolymerization Vinilic Monomers onto CMC
Mohammad Sadeghi, Fatemeh Soleimeni and Hossein Sadeghi

Department of Chemistry, Science FacultyIslamic Azad University,Arak Branch Arak Iran

Email:- m-sadeghi@iau-arak.ac.ir

Abstract :

Graft copolymerization of Buthylmethacrylate (BMC) and Acrylic acid (AcA) onto carboxymethylcellulose (CMC) was carried out under argon atmosphere in a homogeneous aqueous medium by using ceric ammonium nitrate (CAN) as an initiator. Evidence of grafting was obtained by comparison of FTIR spectra of CMC and homopolymer-free CMC-g-poly(AcA-co- BMC). The effect of the concentration of the initiator, monomers and polysaccharide as well as the reaction time and temperature on the graft copolymerization reactions were investigated to achieve the optimum grafting conditions. 
 

Keyword :  carboxymethylcellulose; Buthylmethacrylate; Acrylic acid;graft copolymerization.
DOI : juc
Paper Download Count : 1
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Article No. 18
Mixed Ligand Complexes of Cd(II) Ion with Adipic acid and some Bicarboxylic Acids at DME
Trapti Gupta and C. P. Singh Chandel*

Department of Chemistry,University of Rajasthan Jaipur-302004 India

Email:-chandelcps2@rediffmail.com

Abstract :

The stability constant of mixed ligand complexes of Cd(II) with adipic acid and some bicarboxylic acids (Malonic Acid, L(+)Tartaric Acid, DLMalic Acid, Maleic Acid and Succinic Acid) have been determined electrochemically. The stepwise formation constants of simple CdAdipic acid and CdBicarboxylic acids have been investigated by Deford and Hume's method. Then the mixed ligand complexes of Cd with adipic acid and bicarboxylic acids have been studied by the method of Schaap & McMasters. The mixing constant (KM) and stabilization constant (KS) were measured for the comparison of the simple and mixed ligand complexes. The positive value of mixing constants and stabilization constants show that the ternary complexes are more stable than the binary complexes. 
 

Keyword : Adipic Acid, Bicarboxylic Acids, Stability Constants.
DOI : juc
Paper Download Count : 1
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Article No. 19
Studies on Graft Copolymerization of 2-Hydroxyethylmethacrylate and acrylic acid onto starch
Mohammad Sadeghi*, Fatemeh Soleimani and Hossein Sadeghi

Department of Chemistry, Science FacultyIslamic Azad University,Arak Branch Arak Iran

Email:- m-sadeghi@iau-arak.ac.ir

Abstract :

 Starch has been chemically modified by graft copolymerization of 2-hydroxyethylacrylate (HEMA) and acrylic acid(AcA) an aqueous medium using ammonium persulfate (APS) as an initiator under argon atmosphere. A plausible reaction mechanism of grafting has been suggested. Evidence of grafting was obtained by comparison of FTIR spectra of starch and homopolymer-free St-g-poly(HEMA-co-AcA) as well as solubility characteristics and gravimetric analysis of the products. The optimum reaction conditions affording maximum grafting ratio and add-on value have been determined. The grafting parameters have been found to increase with increasing in starch, APS,AcA and HEMA concentrations up to a certain value, but these parameters decrease on further increasing in reaction conditions. 
 

Keyword : Starch, 2-hydroxyethylmethacrylate,acrylic acid, graft copolymerization.
DOI : juc
Paper Download Count : 1
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Article No. 20
Ultrasonic studies of NaCl in dioxane water solvent at 303.15K
S.R.Swain, P.C.Nayak, I.B.Mohanty* and P.K. Mishra**

*P.G. Department of Chemistry, GM (Auto) College Sambalpur Orissa Inda

**Department of Chemistry, Ravenshaw College ,Cuttak, Orissa India

Abstract :

 Various acoustic parameters like isentropic compressibility (bs) intermolecular free length (Lf) apparent molar volume (f), apparent molar compressibility (fk), molar compressibility (w), molar sound velocity(R), acoustic impedance (z) of NaCl in 10%, 20%, 30% and dioxane+water at 303.15K have been determined from ultrasonic velocity (V), density(r) and relative viscosity (çr) of the solution. These parameters are related with the molar concentration of the solution and reflects the distortion of the structure of the solvent (i.e. dioxane + water) when the solute is added to it.

Keyword : ultrasonic studies
DOI : juc
Paper Download Count : 1
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